Hollywood Reporter said that Louise Fletcher, the sweet actress from Alabama who won an Academy Award for her turn as the heartless Nurse Ratched — one of the most reviled characters in movie history — in One Flew Over the Cuckoo’s Nest, has died. She was 88.

Fletcher died Friday of natural causes at her home in Montdurausse, France, her son Andrew Bick told The Hollywood Reporter. She had survived two bouts with breast cancer.

A daughter of deaf parents — she made one of the most touching acceptance speeches in Oscar history — Fletcher also starred as a psychiatrist in Exorcist II: The Heretic (1977) and played opposite Peter Falk amid the star-studded ensemble in The Cheap Detective (1978).

On television, she portrayed the religious leader Kai Winn Adami on Star Trek: Deep Space Nine and received Emmy nominations in 1996 and 2004 for her guest-starring stints on Picket Fences and Joan of Arcadia, respectively.