Originally based in Colorado Springs, Colorado, U.S. Soccer headquarters were moved to Chicago in 1991 under the leadership of former Secretary General, Hank Steinbrecher Called U.S. Soccer House, it is currently located in two refurbished mansions at 1801 South Prairie Avenue in Chicago.

In 2003, U.S. Soccer opened their National Training Center at Dignity Health Sports Park (then named Home Depot Center) in Carson, California. The $130 million facility includes a soccer-specific stadium, home to the MLS team Los Angeles Galaxy. Additionally, four grass soccer fields, a FieldTurf soccer field and a general training area are specifically dedicated to U.S. Soccer. Both the senior and youth men's and women's US national teams hold regular camps at Dignity Health Sports Park.

U.S. Soccer was also exploring a possibility of building the National Training and Coaching Development Center in Kansas City, Kansas. On April 9, 2015, the Training Center received final approval from the local governments. U.S. Soccer agreed to a 20-year lease, with the project set to break ground in 2016 and finishing some time in 2017.