Aim
Stathmin is a phosphoprotein that plays a role in intercellular and intracellular signalization, inflammation, and differentiation. Our aim was to evaluate the stathmin-2 level and its relationship with the metabolic parameters of newly diagnosed type 2 diabetes mellitus(nT2DM) patients.

Material and Method
This case-control study included 76 patients with nT2DM and 76 healthy individuals with a normal oral glucose tolerance test who were matched for body mass index(BMI), age, and gender. In addition to laboratory and anthropometric measurements related to type 2 diabetes mellitus(T2DM), stathmin-2 levels were determined using an enzyme-linked immunosorbent assay.

Results
We observed significantly higher circulating stathmin-2 levels in subjects with T2DM compared to the control group(6.39±1.60 ng/mL and 4.66±0.80 ng/mL p<0.0001). In patients with metabolic syndrome, circulating stathmin-2 levels were significantly elevated compared to those without metabolic syndrome in both the T2DM and control groups(T2DM:7.16±1.24 vs 5.06±1.24 ng/mL, p<0.001; Control:3.84±1.40 vs 3.82±1.40 ng/mL). In both groups, we observed a positive correlation between stathmin-2 levels and BMI and circumference. Moreover, stathmin-2 showed a positive correlation with high-sensitivity C-reactive protein(hs-CRP), homeostatic model assessment of insulin resistance, insulin, fasting blood glucose, hemoglobin A1c, BMI, low-density lipoprotein cholesterol, and total cholesterol. A negative correlation was observed with stathmin-2 and high-density lipoprotein cholesterol. Stathmin-2 did not show any correlation with age, triglyceride, and lactate dehydrogenase.

Conclusions
Stathmin-2 levels were found to be elevated in patients with nT2DM and exhibited positive correlations with hyperinsulinaemia, hyperglycaemia, HOMO-IR and hs-CRP levels. These results indicate that stathmin-2 may play a role in T2DM pathogenesis.





Sources - https://www.sciencedirect.com/science/article/abs/pii/S0002962924011546