Single dose of LSD highly effective at treating anxiety

By Colin Davidson, University of Central Lancashire

University of Central Lancashire

LSD was accidentally discovered by Albert Hofmann at the Sandoz pharmaceutical company in Switzerland in 1938. It was apparently useless, but from 1947 it was marketed as “a cure for everything from schizophrenia to criminal behavior, ‘sexual perversions’, and alcoholism”. It failed to find its niche.

Now, over 80 years later, it may finally have found one – other than expanding consciousness, that is. A new study shows that it is highly effective at treating generalised anxiety disorder for up to 12 weeks with just a single dose. And it is fast acting.

General anxiety disorder (hereafter referred to simply as “anxiety”) is a mental health condition characterised by excessive worry, fear and anxiety about everyday situations. It affects about 6% of adults during their life. Treatments include psychotherapy, such as cognitive behavioural therapy, as well as medications, such as antidepressants and benzodiazepines.

Psychotherapy is expensive and takes weeks or months, while drugs need to be taken daily for weeks, months or even years. And these can have side-effects. Benzodiazepines are very addictive, while SSRIs (the latest generation of antidepressants) have a variety of side-effects including sexual dysfunction.

In addition, there are many anxious patients for whom none of the established drugs work. Clearly, new drugs for anxiety are needed.

A clinical trial in the US by the biopharmaceutical company MindMed has shown that a form of LSD (lysergide d-tartrate), given at a relatively low dose, can effectively treat people with anxiety.

Patients were given the drug at 25µg, 50µg, 100µg or 200µg. This was a phase 2b clinical trial, which is where different doses of a drug are tested in a group of people with the illness in question. The purpose is to find a dose that works while having acceptable side-effects. It was found that the 100µg dose was very effective while having only relatively minor side-effects.

The study used the Hamilton anxiety scale to measure anxiety levels. Researchers found improvements in anxiety levels within only two days of administration of their drug.

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