Obesity and high GV ( Glycemic Variability)were associated with increased risk of all-site, breast, liver cancer, and cancer-specific death .
The study published in Lancet is from a prospective Hong Kong Diabetes Register cohort (1995-2019). The also explored the joint association of obesity and GV with these outcomes and site-specific cancer. GV was measured using HbA1c - which gives values for blood sugar for at least three months.
With a declining trend of vascular death, aging and increasing population of young patients who face long disease duration, the dual burden of diabetes and cancer will continue to rise . Given the availability of technologies that can reduce obesity and glycaemic variability and that 1 in 4 patients were obese with high GV who had 2-fold increased risk of cancer and related deaths, identification of these high risk patients for intensive management will have important implications on personal and public health.