The defender has been ruled out of the midweek trip to Nottingham, joining Rasmus Hojlund and Luke Shaw on the sidelines, manager Erik ten Hag confirmed on Wednesday. Fellow central defender Raphael Varane and midfielder Bruno Fernandes are also in danger of missing out.

Ten Hag told club media: "We have some question marks in our squad. Harry Maguire will not be available. Bruno is doubtful. Also Rapha Varane is doubtful. We have to watch and see what we will have and then pick a team, with the aim of course [of winning]. It's an FA Cup game, so it's about win or lose. Black or white. We have to win and that should be our approach."

With Maguire out and Varane possibly following, United have only Jonny Evans, Willy Kambwala and Victor Lindelof available to play at centre-back. Lindelof played on the left side of the defence in Shaw's absence against Fulham last week, meaning all three could start.